Introduction
Ceftax 500 IV/IM is an antibiotic medicine used to treat bacterial infections in your body. It is effective in infections of the brain, lungs, ear, urinary tract, skin and soft tissues, bones and joints, blood and heart. It is also used to prevent infections during surgery.
Ceftax 500 IV/IM fights and stops the growth of many types of bacteria. This helps to improve your symptoms and cure the underlying infection. It is given as a drip (intravenous infusion) or as an injection directly into a vein or a muscle under the supervision of a healthcare professional. Your doctor will decide the correct dose for you. You should use this medicine regularly at evenly spaced intervals as per the schedule prescribed by your doctor. Do not skip any doses and finish the full course of treatment even if you feel better. Stopping the medicine too early may lead to the infection returning or worsening.
The most common side effects of this medicine include rash and diarrhoea. Some people may develop temporary redness or pain at the site of injection. These side effects are usually mild but let your doctor know if they bother you or last more than a few days.
Before using it, you should tell your doctor if you are allergic to any antibiotics, and if you have any liver or kidney problems. You should also let your healthcare team know all other medicines you are taking as they may affect, or be affected by this medicine. Pregnant and breastfeeding mothers should consult their doctor before using it.
Side effects of Ceftax 500 IV/IM
Common
- Rash
- Allergic reaction
- Nausea
- Injection site reaction
- Diarrhea
How to use Ceftax 500 IV/IM
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Ceftax 500 IV/IM works
Ceftax 500 IV/IM is an antibiotic. It kills the bacteria by preventing them from forming the bacterial protective covering (cell wall) which is needed for them to survive.
What if you forget to take Ceftax 500 IV/IM?
If you miss a dose of Ceftax 500 IV/IM, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Indication
Pneumonia, Meningitis, Peritonitis, Pelvic inflammatory disease, Endometritis, Pelvic cellulitis, Gonorrhea, Skin and skin structure infections, Respiratory tract infections, Urinary tract infections, Bacteremia/Septicemia, Bone and/or joint infections
Administration
IV Preparation
Intermittent injection: Reconstitute 1 or 2 g with 10 mL SWI
Infusion: Reconstitute infusion bottles with 50 or 100 mL NS or D5W
IM: Add 2 mL, 3 mL or 5 mL of sterile or bacteriostatic water for inj to a vial
Adult Dose
Adult:
Infections Caused by Susceptible Organisms
Uncomplicated: 1 g IV or IM q12hr
Moderate to severe: 1-2 g IV or IM q8hr
More serious (bloodstream infection [septicemia]): 2 g IV q6-8hr
Life-threatening: 2 g IV q4hr; not to exceed 12 g/day
Surgical prophylaxis 1 g 30-90 mins before procedure.
Gonorrhoea 0.5-1 g as a single dose.
Child Dose
Children: IV, IM 50–180 mg/kg/day q6–8h
200–225 mg/kg/day for meningitis q6h
Neonates:
The recommended dosage is 50 mg/kg/day in 2 to 4 divided doses. In severe infections 150-200 mg/kg/day in divided doses have been given.
Renal Dose
Renal impairment: Severe: After an initial loading dose of 1 g, half the daily dose w/o changing the frequency.
Contraindication
Hypersensitivity to cephalosporins.
Mode of Action
Cefotaxime binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death.
Precaution
History of penicillin allergy; colitis; impaired renal function; pregnancy, lactation.
Lactation: Drug enters breast milk; use with caution
Side Effect
Colitis, Elevated blood urea nitrogen (BUN) and creatinine, Elevated hepatic transaminases, Fever. Pain at inj site; hypersensitivity reactions, rash, pruritus; diarrhoea, nausea, vomiting; candidiasis; eosinophilia, neutropenia, leucopenia, thrombocytopenia.
Potentially Fatal: Anaphylactic reaction; nephrotoxicity.
Pregnancy Category Note
Pregnancy category: B
Lactation: Drug enters breast milk; use with caution
Interaction
Probenecid decreases cefotaxime elimination.
Potentially Fatal: Nephrotoxicity with furosemide and aminoglycosides.