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Advixa 40
Incepta Pharmaceuticals Ltd.
Generic: Adalimumab
Safety Advices
বাংলা
English
SAFE
Consuming alcohol with Advixa 40 does not cause any harmful side effects.
SAFE IF PRESCRIBED
Advixa 40 is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
SAFE IF PRESCRIBED
Advixa 40 is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
UNSAFE
Advixa 40 may cause side effects which could affect your ability to drive.
Advixa 40 may cause room spinning sensation and vision disturbances. This may affect your driving ability.
CONSULT YOUR DOCTOR
There is limited information available on the use of Advixa 40 in patients with kidney disease. Please consult your doctor.
CONSULT YOUR DOCTOR
There is limited information available on the use of Advixa 40 in patients with liver disease. Please consult your doctor.
Medicine Overview of Advixa 40mg/0.4ml Injection
Introduction
Advixa 40 is a medicine used to treat a variety of conditions such as ankylosing spondylitis, rheumatoid arthritis, psoriasis, ulcerative colitis, and Crohn’s disease. It provides relief from swelling, pain, and redness associated with various disorders and improves physical function. Advixa 40 is given by a healthcare professional and should not be self-administered. You should use it regularly and at the same time each day to get the maximum benefit from it. Continue using it as recommended by your doctor and complete the dose even if you feel better. Some of the common side effects of this medicine include headache,...
... Show moreUses of Advixa 40
- Ankylosing spondylitis
- Rheumatoid arthritis
- Psoriasis
- Ulcerative Colitis
- Crohn’s disease
Side effects of Advixa 40
Common
- Headache
- Sinus inflammation
- Rash
- Upper respiratory tract infection
- Injection site reaction
How to use Advixa 40
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Advixa 40 works
Advixa 40 blocks the action of certain chemical messengers that are responsible for inflammation, swelling and redness associated with certain joint diseases.
What if you forget to take Advixa 40?
If you miss a dose of Advixa 40, please consult your doctor.
Quick Tips
- It is given by injection under the skin (via subcutaneous).
- Take it as per the dose and duration suggested by the doctor.
- Inform your doctor immediately if you notice severe rash, hives, swelling of hands or face and shortness of breath.
- Store the pen in the refrigerator. When refrigeration is not possible, you can also keep your pen at room temperature (less than 30°C) for up to 2 weeks. Do not freeze it.
- Do not stop taking the medication suddenly without talking to your doctor first.
Brief Description
Indication
Rheumatoid arthritis, Ankylosing spondylitis; Psoriatic arthritis, Crohn's disease; Ulcerative colitis, Plaque psoriasis, Juvenile Rheumatoid Arthritis
Administration
Instruct patients using the pen or prefilled syringe to inject the full amount in the syringe, according to the directions provided
Injections should occur at separate sites in the thigh or abdomen; rotate injection sites and do not give injections into areas where the skin is tender, bruised, red, or hard
Adult Dose
Subcutaneous Rheumatoid arthritis, Ankylosing spondylitis, Psoriatic arthritis Adult: 40 mg as a single dose every other wk. May increase to wkly dosing when used as monotherapy. Crohn's disease, Ulcerative colitis Adult: Moderate to severe active disease: Initially, 160 mg (given as four 40-mg inj in 1 day or as two 40-mg inj for 2 consecutive days), then 80 mg 2 wk after the initial dose (day 15). Maintenance: After 2 wk (day 29), 40 mg every other wk, may increase to 40 mg wkly if needed. Review treatment if no response w/in 8 (ulcerative colitis) or 12 (Crohn's disease) wk...
... Show moreChild Dose
Subcutaneous
Juvenile idiopathic arthritis
Child: >4 yr 15 to 30 kg: 40 mg every other wk.
Contraindication
None listed on FDA-approved label.
Mode of Action
Adalimumab is a recombinant DNA-derived human Ig G1 monoclonal antibody. It binds to human tumour necrosis factor alfa (TNF-alpha), thus interfering w/ cytokine-driven inflammatory processes.
Precaution
Patient w/ pre-existing or recent onset central or peripheral nervous system demyelinating disorders, heart failure or decreased left ventricular function; at risk of hepatitis B virus (HBV) infection. Reactivation and new onset of TB infection. Patient who travelled to or resided in regions where TB is endemic. Elderly. Pregnancy and lactation. Monitoring Parameters Perform tuberculin skin test and HBV screening prior to treatment. Monitor for signs and symptoms of infection prior to, during and following treatment. Lactation: Limited data from published literature indicate that adalimumab is present in low levels in human milk and is not likely to be absorbed...
... Show moreSide Effect
>10%
Injection site pain (12-20%),Upper respiratory tract infection (URTI) (17%),Increased creatine phosphokinase (15%),Headache (12%),Rash (12%),Sinusitis (11%)
1-10%
Nausea (9%),Urinary tract infection (UTI) (8%),Abdominal pain (7%),Flulike syndrome (7%),Hyperlipidemia (7%),Back pain (6%),Hypercholesterolemia (6%),Hematuria (5%),Hypertension (5%),Increased alkaline phosphatase (5%)
<1%
Allergic reactions,Hematologic disorder (leukopenia, thrombocytopenia, pancytopenia, aplastic anemia)
Potentially Fatal: Sepsis, opportunistic infections, TB, HBV reactivation, other malignancies (e.g. leukaemia, lymphoma, hepatosplenic T-cell lymphoma), haematological, neurological and autoimmune reactions, anaphylaxis, angioneurotic oedema.
Pregnancy Category Note
Pregnancy Available studies with use of adalimumab during pregnancy do not reliably establish an association between adalimumab and major birth defects Clinical data are available from the Organization of Teratology Information Specialists (OTIS)/Mother-To-Baby HUMIRA Pregnancy Registry in pregnant women with rheumatoid arthritis (RA) or Crohn disease (CD) Registry results showed a rate of 10% for major birth defects with first trimester use of adalimumab in pregnant women with RA or CD and a rate of 7.5% for major birth defects in the disease matched comparison cohort The lack of pattern of major birth defects is reassuring and differences between exposure...
... Show moreInteraction
Increased risk of serious infections w/ other biologic disease-modifying antirheumatic drugs (e.g. abatacept, anakinra), rituximab. May increase immunosuppressant effect w/ tocilizumab, live vaccines.
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