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Diastat 25
The White Horse Pharmaceuticals Ltd
Generic: Empagliflozin
Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Diastat 25.
CONSULT YOUR DOCTOR
Diastat 25 may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
CONSULT YOUR DOCTOR
Information regarding the use of Diastat 25 during breastfeeding is not available. Please consult your doctor.
CAUTION
Your ability to drive may be affected if your blood sugar is too low or too high. Do not drive if these symptoms occur.
UNSAFE
Diastat 25 is probably unsafe to use in patients with kidney disease and should be avoided. Please consult your doctor.
CAUTION
Diastat 25 should be used with caution in patients with severe liver disease. Dose adjustment of Diastat 25 may be needed. Please consult your doctor.
Medicine Overview of Diastat 25mg Tablet
Introduction
Diastat 25 is used alone or in combination with other medicines to treat type 2 diabetes mellitus. It helps control the high blood sugar levels seen in diabetes. This reduces the chances of serious complications of diabetes and also helps prevent heart disease. Diastat 25 can be taken with or without food at any time of day but you should try to take it at the same time every day. The dose will be decided by your doctor. Do not stop taking it without asking your doctor. If you do, your blood sugar levels may increase and put you at...
... Show moreUses of Diastat 25
- Type 2 diabetes mellitus
Side effects of Diastat 25
Common
- Frequent urge to urinate
- Genital fungal infection
- Increased thirst
- Nausea
- Urinary tract infection
How to use Diastat 25
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Diastat 25 may be taken with or without food, but it is better to take it at a fixed time.
How Diastat 25 works
Diastat 25 is an antidiabetic medication. It works by removing excess sugar from your body through urine.
What if you forget to take Diastat 25?
If you miss a dose of Diastat 25, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- Diastat 25 is used alone or together with other diabetes medicines to control blood sugar and avoid long-term complications.
- It may cause your body to lose too much fluid (dehydration) or you may urinate more often. Drink plenty of water and stay hydrated.
- It may cause hypoglycemia (low blood sugar level) when used with other antidiabetic medicines, alcohol or if you delay or miss a meal.
- Always carry some sugary food or fruit juice with you in case you experience hypoglycemia symptoms such as cold sweats, cool pale skin, tremor and anxiety.
- It can cause genital fungal and/or urinary tract infections (UTIs) in both females and males, so practice good hygiene.
- Monitor your blood sugar regularly while taking this medicine.
- Inform your doctor immediately if you experience constant dizziness, joint pain, cold-like symptoms or unexplained nausea/vomiting.
Brief Description
Indication
Type 2 diabetes mellitus
Administration
May be taken with or without food.
Adult Dose
Oral
Type 2 diabetes mellitus
Adult: Initially, 10 mg once daily in the morning, may be increased to 25 mg once daily, if necessary for additional glycemic control.
Renal Dose
CrCl (mL/min)
<45 Contraindicated.
<60 Max: 10 mg daily.
Contraindication
As treatment for type 1 DM or diabetic ketoacidosis. Renal impairment (CrCl <45 mL/min), ESRD, or patients on haemodialysis. Lactation.
Mode of Action
Empagliflozin is a reversible inhibitor of sodium-glucose co-transporter 2 (SGLT2), the main site of filtered glucose re-absorption in the renal proximal convoluted tubules. This reduces re-absorption of filtered glucose and lowers renal threshold for glucose, resulting in increased urinary glucose excretion, thereby reducing blood glucose concentration.
Precaution
Hypotension: Before initiating Empagliflozin, volume status should be assessed and correction on hypovolemia should be made in the elderly, in patients with renal impairment, in patients with low systolic blood pressure and in patients on diuretics since Empagliflozin causes intravascular volume contraction. Impairment in Renal Function: Renal function should be evaluated prior to initiating Empagliflozin and periodically thereafter since Empagliflozin increases serum creatinine and decreases eGFR. Hypoglycemia: In patients taking insulin or an insulin secretagogue with Empagliflozin, a lower dose of insulin or the insulin secretagogue is considered to reduce the risk of hypoglycemia. Genital mycotic infections: Monitoring and treatment...
... Show moreSide Effect
1-10%
Urinary tract infection (7.6-9.3%)
Female genital mycotic infections (5.4-6.4%)
Upper respiratory tract infection (3.1-4%)
Increased urination (3.2-3.4%)
Dyslipidemia (2.3-2.4%)
Male genital mycotic infections (1.6-3.1%)
Nausea (1.1-2.3%)
Polydipsia (1.5-1.7%)
Pregnancy Category Note
Pregnancy Based on animal data showing adverse renal effects, use not recommended during the second and third trimesters of pregnancy Limited data available in pregnant women are insufficient to determine a drug-associated risk for major birth defects and miscarriage There are risks to the mother and fetus associated with poorly controlled diabetes in pregnancy Clinical considerations Poorly controlled diabetes in pregnancy increases maternal risk for diabetic ketoacidosis, pre-eclampsia, spontaneous abortions, preterm delivery, stillbirth, and delivery complications; poorly controlled diabetes increases fetal risk for major birth defects, still birth, and macrosomia related morbidity Lactation There is no information regarding presence in...
... Show moreInteraction
Additive hypoglycaemic effect if concomitantly used w/ insulin and insulin secretagogues (e.g. sulfonylureas). Increased risk of dehydration and hypotension when used w/ diuretics (e.g. thiazides, loop diuretics).
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