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Cilanem 500
Eskayef Pharmaceuticals Ltd.
Generic: Imipenem + Cilastatin
Safety Advices
বাংলা
English
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Cilanem 500. Please consult your doctor.
CONSULT YOUR DOCTOR
Cilanem 500 may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
SAFE IF PRESCRIBED
Cilanem 500 is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
UNSAFE
Cilanem 500 may cause side effects which could affect your ability to drive.
There are some side effects associated with this medicine (such as seeing, hearing, or feeling something that is not there) that may affect some patients' ability to drive.
CAUTION
Cilanem 500 should be used with caution in patients with kidney disease. Dose adjustment of Cilanem 500 may be needed. Please consult your doctor.
CONSULT YOUR DOCTOR
There is limited information available on the use of Cilanem 500 in patients with liver disease. Please consult your doctor.
Medicine Overview of Cilanem 500mg+500mg IV/IM Injection
Introduction
Cilanem 500 is a combination of antibiotic medicines. It is prescribed to treat various types of severe bacterial infections. It fights against the infection-causing microorganisms to prevent further infections. Cilanem 500 should only be administered under the supervision of a healthcare professional. Do not miss any scheduled appointments for taking this medicine. The course of the medicine should be completed even if you feel better. The common side effects of this medicine are nausea, vomiting, diarrhea, rashes, etc. You may also experience injection site redness, swelling, and pain that goes away with time. If any of the side effects get...
... Show moreUses of Cilanem 500
- Severe bacterial infections
Side effects of Cilanem 500
Common
- Nausea
- Vomiting
- Diarrhea
- Rash
How to use Cilanem 500
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Cilanem 500 works
Cilanem 500 is a combination of two medicines: Imipenem and Cilastatin. Imipenem is an antibiotic. It works by preventing the formation of the bacterial protective covering which is essential for the survival of bacteria in the human body. Cilastatin is dehydropeptidase I inhibitor which blocks the activity of an enzyme (dehydropeptidase I) that causes breakdown of Imipenem. Hence, it helps Imipenem stay active in your body for a longer period of time.
Quick Tips
- Cilanem 500 is used to treat severe bacterial infections, including those acquired in hospital and those involving many different types of bacteria.
- It is given by a drip into a vein (intravenous infusion) over 20 to 60 minutes.
- Tell you doctor if you are allergic to penicillin as this medicine should be avoided or used with caution in penicillin allergy.
- Your doctor may monitor your liver and kidney function while you are having treatment with this medication.
- Diarrhea may occur as a side effect but should stop when your course is complete. Inform your doctor if it doesn't stop or if you find blood in your stools.
- Inform your doctor if you are pregnant, planning to conceive, or breastfeeding.
Brief Description
Indication
Cystic fibrosis, Bacterial septicemia, Endocarditis, Susceptible infections, Lower Respiratory Tract Infections, Gonorrhea, Skin and skin structure infections, Urinary tract infections, Bone and Joint Infections, Surgical Prophylaxis
Administration
IV Preparation Reconstitute infusion bottles with 100 mL of compatible diluent Reconstitute vials with a portion (usually 10 mL) of IV fluid withdawn from the IV container, dissolve, and return to container; repeat Reconstituted solutions are stable for 4 hours at room temperature and 24 hours refrigerated (4 C) in NS Normal color ranges from clear to yellow; these variations do not affect potency, but solution should be discarded if brown IV Administration Do not administer by IV push Final concentration should not exceed 5 mg/mL Infuse 500 mg over 40-60 min Vial contents must be transferred to 100 mL...
... Show moreAdult Dose
Lower Respiratory Tract, Skin/Skin Structure, & Gynecologic Infections Mild to moderate: 500-750 mg IV q12hr Intra-abdominal Infections Mild to moderate: 250-500 mg IV q6hr Severe: 500 mg IV q6hr or 1 g q8hr for 4-7 days, provided that infection is brought under control Pseudomonas Infections 500 mg IV q6hr; higher dosages may be administered, depending on organism sensitivity Urinary Tract Infections Uncomplicated: 250 mg IV q6hr Complicated: 500 mg IV q6hr Susceptible infections Moderate infections IV: Fully susceptible organisms: 500 mg IV q6-8hr Moderately susceptible organisms: 500 mg IV q6hr or 1 g IV q8hr Severe infections Fully susceptible organisms:...
... Show moreChild Dose
Child: IV, IM 60–100 mg/kg/day q6h
IM form not approved for <12 y
Renal Dose
Renal impairment:
CrCl (ml/min)
31-70 500 mg every 6-8 hr
21-30 500 mg every 8-12 hr
6-20 250 mg or 3.5 mg/kg (whichever is lower) every 12 hr
<5 Only give if haemodialysis started within 48 hr
Contraindication
Hypersensitivity.
Mode of Action
Imipenem is a potent inhibitor of bacterial cell wall synthesis and is bactericidal against a broad spectrum of pathogens. It is resistant to degradation by bacterial beta-lactamases. Cilastatin is an inhibitor of dehydropeptidase I, an enzyme found in the brush border of the renal tubules. It is given as the sodium salt with imipenem to prevent its renal metabolism and protect against nephrotoxic effects.
Precaution
Caution when used in patients with known hypersensitivity to other beta-lactams due to possibility of cross-sensitivity. CNS disorders such as epilepsy; renal, hepatic impairment; pregnancy, lactation.
Lactation: Drug distributed in breast milk; use with caution
Side Effect
1-10%
Phlebitis (2-5%),Eosinophilia (4%),Miscellaneous dermatologic effects (<3%),Potentially false-positive Coombs test (2%),Miscellaneous hematologic effects (<2%),Transient increase in blood urea nitrogen (BUN) or serum creatinine (<2%),Seizures (1.5%),Nausea, diarrhea, vomiting (1-2%)
<1%
Abnormal urinalysis,Agitation,Anaphylaxis,Anemia,Confusion (acute),Dizziness,Dyskinesia,Emergence of resistant strains of Pseudomonas aeruginosa,Fever,Hypersensitivity,Hypotension,Elevated liver function test (LFT) results,Increased prothrombin time (PT),Neutropenia (including agranulocytosis),Palpitations,Pruritus,Pseudomembranous colitis
Potentially Fatal: Stevens-Johnson syndrome, toxic epidermal necrolysis.
Interaction
Concurrent admin with probenecid may increase the half-life of cilastatin. Increased risk of generalised seizures when used concurrently with ganciclovir.
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