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Coxsafe 120
Sharif Pharmaceuticals Ltd.
Generic: Etoricoxib
Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Coxsafe 120.
CONSULT YOUR DOCTOR
Coxsafe 120 may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
CONSULT YOUR DOCTOR
Information regarding the use of Coxsafe 120 during breastfeeding is not available. Please consult your doctor.
UNSAFE
Coxsafe 120 may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
CAUTION
Coxsafe 120 should be used with caution in patients with kidney disease. Dose adjustment of Coxsafe 120 may be needed. Please consult your doctor.
Use of Coxsafe 120 is not recommended in patients with severe kidney disease.
CAUTION
Coxsafe 120 should be used with caution in patients with liver disease. Dose adjustment of Coxsafe 120 may be needed. Please consult your doctor.
Use of Coxsafe 120 is not recommended in patients with severe liver disease.
Medicine Overview of Coxsafe 120mg Tablet
Introduction
Coxsafe 120 is a pain relieving medicine. It is used for relieving moderate pain and swelling of joints associated with different forms of gout and arthritis. It is also used for short-term treatment of moderate pain after dental surgery in people 16 years of age and older. Coxsafe 120 can be taken with or without food. The dose depends on what you are taking it for and how well it helps your symptoms. You should take it as advised by your doctor. Do not take more or use it for longer than recommended. The most common side effects of this...
... Show moreUses of Coxsafe 120
- Pain relief
Side effects of Coxsafe 120
Common
- Stomach pain
- Diarrhea
How to use Coxsafe 120
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Coxsafe 120 may be taken with or without food, but it is better to take it at a fixed time.
How Coxsafe 120 works
Coxsafe 120 is a non-steroidal anti-inflammatory drug (NSAID) called COX-2 inhibitors. It works by blocking the release of certain chemical messengers that are responsible for pain and inflammation (redness and swelling).
Quick Tips
- Coxsafe 120 helps relieve pain and inflammation.
- It may cause fewer stomach problems as compared to other NSAIDs like Ibuprofen or Naproxen.
- It may cause dizziness and fatigue. Do not drive or do anything requiring concentration until you know how it affects you.
- Do not consume alcohol while on treatment with this medicine as it may cause excessive drowsiness.
- Regularly monitor your blood pressure while taking this medicine, particularly in the first two weeks after starting treatment.
- Inform your doctor if you have a history of stomach ulcers, heart diseases, high blood pressure, and liver or kidney disease.
- During long-term treatment, your doctor may want to take regular blood tests to monitor your liver function.
- Do not take Coxsafe 120 if you are pregnant, planning to conceive, or breastfeeding.
Brief Description
Indication
Rheumatoid arthritis, Osteoarthritis, Gout
Administration
May be taken with or without food.
Adult Dose
Oral
Osteoarthritis
Adult: 30 mg once daily, increased to 60 mg once daily if needed.
Ankylosing spondylitis; Rheumatoid arthritis
Adult: 90 mg once daily.
Acute gout
Adult: 120 mg once daily. Max duration: 8 days.
Hepatic impairment: Mild (Child-Pugh score of 5-6): 60 mg once daily.
Moderate (Child-Pugh 7-9): Max 60 mg every other day or 30 mg once daily.
Severe (Child-Pugh >10): Avoid.
Child Dose
Child: <16 yr Contraindicated.
Contraindication
Inflammatory bowel disease, severe congestive heart failure, active peptic ulceration, cerebrovascular disease, CrCL <30 ml/min; lactation. Children and adolescent < 16 yr.
Mode of Action
Etoricoxib is a selective cyclooxygenase-2 (COX-2) inhibitor primarily responsible to reduce mediators of pain and inflammation. Its action is due to inhibition of prostaglandin synthesis via inhibition of COX-2.
Precaution
Allergic disorders, coagulation defects; history of cardiac failure, left ventricular dysfunction, hypertension, or in patients with oedema due to other reasons; elderly, renal, cardiac or hepatic impairment. Withdraw treatment if GI lesions develop; caution when admin to dehydrated patients. Regular BP monitoring is advisable. May mask fever and other signs of infection. Pregnancy.
Side Effect
GI disorders; ischemic cardiac events; hypersensitivity reactions, headache, dizziness, nervousness, depression, drowsiness, insomnia, vertigo, tinnitus, photosensitivity; blood disorders, fluid retention, hypertension; dry mouth, taste disturbance, mouth ulcers; appetite and wt changes; chest pain, fatigue, paraesthesia, influenza-like syndrome, myalgia. Renal toxicity.
Interaction
May increase INR w/ oral anticoagulants. May decrease effects of ACE inhibitors, angiotensin II antagonist and diuretics. May increase lithium plasma concentrations. May reduce plasma levels w/ rifampicin. Increased serum concentrations of ethinylestradiol.
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