12-24 Hours
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Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Epastat 50.
CONSULT YOUR DOCTOR
Information regarding the use of Epastat 50 during pregnancy is not available. Please consult your doctor.
CONSULT YOUR DOCTOR
Information regarding the use of Epastat 50 during breastfeeding is not available. Please consult your doctor.
CONSULT YOUR DOCTOR
It is not known whether Epastat 50 alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.
CONSULT YOUR DOCTOR
There is limited information available on the use of Epastat 50 in patients with kidney disease. Please consult your doctor.
CONSULT YOUR DOCTOR
There is limited information available on the use of Epastat 50 in patients with liver disease. Please consult your doctor.
Medicine Overview of Epastat 50mg Tablet
Introduction
Epastat 50 is used to treat diabetic nerve pain. Poorly controlled diabetes can eventually lead to diabetic nerve disease (neuropathy) as a complication. This medicine helps to relieve symptoms like burning pain and numbness seen in people with diabetic nerve disease. Epastat 50 belongs to a group of medicines known as Aldose reductase inhibitors. It can be taken with or without food but you should try to take it at the same time every day. This will help you to remember to take it. The dose and how often you need it will be decided by your doctor so that...
... Show moreUses of Epastat 50
- Diabetic nerve pain
Side effects of Epastat 50
Common
- Nausea
- Vomiting
- Abnormal liver function
How to use Epastat 50
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Epastat 50 may be taken with or without food, but it is better to take it at a fixed time.
How Epastat 50 works
Epastat 50 is an aldose reductase inhibitor. It blocks the accumulation of sorbitol in cells, which has been related to causing diabetic nerve disease.
What if you forget to take Epastat 50?
If you miss a dose of Epastat 50, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- Adherence to antidiabetic therapy can delay the onset of or prevent diabetic nerve disease.
- If you have existing diabetic nerve disease, wear proper footwear and examine your feet every day to detect lesions early.
- If you have a foot injury or open wound, avoid engaging in weight-bearing activities.
Brief Description
Indication
Diabetic neuropathy
Adult Dose
Oral
Diabetic neuropathy
Adult: 50 mg tid.
Contraindication
Hypersensitivity. Pregnant or breastfeeding.
Mode of Action
Epalrestat is aldose reductase inhibitor. The aldose reductase inhibitors have a distinct mechanism of action, affecting the underlying disease process in diabetic neuropathy, although the extent of the polyol pathway involvement is yet to be determined. Epalrestat reduces sorbitol accumulation in the sciatic nerve, erythrocytes. Epalrestat may improve motor and sensory nerve conduction velocity and subjective neuropathy symptoms.
Precaution
Urine may turn yellowish brown or reddish after taking the medicine, because the yellowish brown or reddish color is attributed to components of this medicine.
Side Effect
The most commonly reported adverse reactions include abdominal pain, nausea, rash, itch, erythema and blister.
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