ব্যবসার জন্য পাইকারি দামে পণ্য কিনতে রেজিস্টেশন করুন

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Nevalto

Name: Nevalto 5mg+80mg tablet
Brand: Beximco Pharmaceuticals Ltd.
SKU: ARG-MED-P-71829
Price: 202.5 BDT
Availability: InStock
Rating: 4.9 (7 reviews)

tablet - (5mg+80mg)

0.0/5

(0) Ratings

Beximco Pharmaceuticals Ltd.

Generic: Nebivolol + Valsartan

Medicine Overview of Nevalto 5mg+80mg tablet

বাংলা

English

Brief Description

Indications

This is a combination product containing beta adrenergic blocker and an angiotensin II receptor blocker (ARB) indicated for the treatment of hypertension, to lower blood pressure. Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions.

Pharmacology

Nebivolol is a cardiovascular drug belonging to the group of selective beta-blocking agents (i.e. with a selective action on the cardiovascular system). It prevents increased heart rate and controls heart pumping strength. It also widens blood vessels which helps to lower blood pressure. Valsartan blocks the action of angiotensin II receptor by acting on AT1 subtype, dilates blood vessels and reduces blood pressure without affecting pulse rate.

Dosage & Administration

As initial therapy and in patients not adequately controlled on valsartan 80 mg or nebivolol up to and including 10 mg, the recommended dose of 5 mg/80 mg (nebivolol/valsartan) is one tablet, taken orally once daily. Maximum antihypertensive effects are attained within 2 to 4 weeks. Increasing the dose of nebivolol/valsartan 5/80 does not result in any meaningful further blood pressure reduction. 5/80 may be substituted for its components in patients already receiving 5 mg nebivolol and 80 mg valsartan.

Interaction

CYP2D6 enzyme inhibitors increase nebivolol levels & Reserpine or clonidine may produce excessive reduction of sympathetic activity.Digitalis glycosides increase the risk of bradycardi & Verapamil-or diltiazem-type calcium channel blockers may cause excessive reductions in heart rate, blood pressure, and cardiac contractility. Potassium sparing diuretics, potassium supplements or salt substitutes may lead to increases in serum potassium besides that, NSAID use may lead to increased risk of renal impairment and loss of antihypertensive effect.Dual inhibition of the renin-angiotensin system: Increased risk of renal impairment, hypotension, and hyperkalemia.

Contraindications

This is contraindicated in the following conditions: Severe bradycardia Heart block greater than first degree Patients with cardiogenic shock Decompensated cardiac failure Sick sinus syndrome (unless a permanent pacemaker is in place) Patients with severe hepatic impairment (Child-Pugh >B) Patients who are hypersensitive to any component of this product Do not co-administer aliskiren with 5/80 in patients with diabetes

Side Effects

Hypotension Hyperkalemia

Pregnancy & Lactation

This can cause fetal harm when administered to a pregnant woman. Not recommended during pregnancy. Advise not to breastfeed.

Precautions & Warnings

Acute exacerbation of coronary artery disease upon cessation of therapy: Do not abruptly discontinue. Diabetes: Monitor glucose as -blockers may mask symptoms of hypoglycemia. In susceptible patients: Need to monitor renal function and potassium level.

Use in Special Populations

Pediatric Use: Safety and effectiveness in pediatric patients have not been established.Geriatric Use: No overall differences in safety or effectiveness were observed between elderly patients and younger patients, and other reported clinical experience have not identified differences in responses.Renal Impairment: This is not recommended as initial treatment in patients with severe renal impairment, because the recommended starting dose of nebivolol in this population, 2.5 mg once daily.Hepatic Impairment: There are no studies of Nebivolol/Valsartan in patients with hepatic insufficiency.

Overdose Effects

Nebivolol: If overdose occurs, provide general supportive and specific symptomatic treatment. Bradycardia: Administer IV atropine. Hypotension: Administer IV fluids and vasopressors. Intravenous glucagon may be useful. Heart Block (second or third degree): Monitor and treat with isoproterenol infusion. Under some circumstances, transthoracic or transvenous pacemaker placement may be necessary. Congestive Heart Failure: Initiate therapy with digitalis glycoside and diuretics.In certain cases, consider the use of inotropic and vasodilating agents. Bronchospasm: Administer bronchodilator therapy such as a short acting inhaled 2-agonist and/or aminophylline. Hypoglycemia: Administer IV glucose.Repeated doses of IV glucose or possibly glucagon may be required. Supportive measures should continue...

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Therapeutic Class

Combined antihypertensive preparations

Storage Conditions

Do not store above 30°C. Keep in a dry place. Protect from light and keep out of the reach of children.

ব্যবসার জন্য পাইকারি দামে পণ্য কিনতে রেজিস্টেশন করুন

0 People recently viewed this

Nevalto

tablet - (5mg+80mg)

0.0/5

(0) Ratings

Beximco Pharmaceuticals Ltd.

Generic: Nebivolol + Valsartan

Additional Offers

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৳100

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৳80

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৳60

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৳40

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৳20

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Disclaimer

The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.