12-24 Hours
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Caripran 1.5
Incepta Pharmaceuticals Ltd.
Generic: Cariprazine
Medicine Overview of Caripran 1.5 1.5mg capsule
বাংলা
English
Indication
Schizophrenia, Indicated for acute treatment of manic or mixed episodes associated with, bipolar disorder
Administration
Take orally with or without food
Adult Dose
Adults Schizophrenia Starting dose: 1.5 mg PO qDay Dose may be increased to 3 mg/day on Day 2 Depending upon clinical response and tolerability, further dose adjustments can be made in 1.5 to 3-mg increments Dosage range: 1.5-6 mg PO qDay Bipolar Disorder Indicated for acute treatment of manic or mixed episodes associated with bipolar I disorder Starting dose: 1.5 mg PO qDay Dose should be increased to 3 mg/day on Day 2 Depending on clinical response and tolerability, further dose adjustments can be made in 1.5 to 3-mg increments Dosage range: 3-6 mg PO qDay Hepatic impairment Mild-to-moderate (Child-Pugh...
... Show moreRenal Dose
Renal impairment
Mild-to-moderate (CrCl ?30 mL/min): No dosage adjustment required
Severe (CrCl <30 mL/min): Not recommended; safety and efficacy has not been established
Contraindication
History of hypersensitivity to cariprazine
Mode of Action
Precise mechanism by which cariprazine works for schizophrenia or bipolar disorder is unknown
Efficacy could be mediated through a combination of partial agonist activity at central dopamine (D2) and serotonin 5-HT1A receptors
Forms 2 major metabolites, desmethyl cariprazine (DCAR) and didesmethyl cariprazine (DDCAR), that have in vitro receptor binding profiles similar to the parent drug
Precaution
Antipsychotic drugs increase the all-cause risk of death in elderly patients with dementia-related psychosis; a higher incidence of stroke and TIA, including fatal stroke, was also observed (see Black Box Warnings) Hypersensitivity reactions have ranged from rash, pruritus, urticaria, and events suggestive of angioedema (eg, swollen, tongue, lip swelling, face edema, pharyngeal edema, facial swelling) Neuroleptic malignant syndrome reported; monitor for hyperpyrexia, muscle rigidity, delirium, and autonomic instability; other signs include increased CPK, myoglobinuria (rhabdomyolysis), and acute renal failure; if NMS is suspected, immediately discontinue treatment Tardive dyskinesia, a potentially irreversible, involuntary, dyskinetic movement syndrome, may develop in patients treated...
... Show moreSide Effect
>10% (Schizophrenia) Extrapyramidal symptoms, all (24-33%) Parkinsonism (13-18%) Headache (9-18%) Akathisia (9-14%) Insomnia (11-13%) >10% (Bipolar Disorder) Extrapyramidal symptoms, all (41-45%) Parkinsonism (21-26%) Akathisia (20-21%) Headache (13-14%) Nausea (11-13%) Constipation (6-11%) 1-10% (Schizophrenia) Constipation (6-10%) Somnolence (5-10%) Nausea (5-8%) Abdominal pain (3-7%) Restlessness (4-6%) Anxiety (3-6%) Toothache (3-6%) Hypertension (2-6%) Dyspepsia (4-5%) Vomiting (4-5%) Dizziness (3-5%) Agitation (3-5%) Diarrhea (1-5%) Pain in extremity (2-4%) Cough (1-4%) Tachycardia (2-3%) Increased weight (2-3%) Decreased appetite (1-3%) Dry mouth (1-3%) Fatigue (1-3%) Increased CPK (1-3%) Musculoskeletal stiffness (1-3%) Back pain (1-3%) Dystonia (2%) Tachycardia (1-2%) Arthralgia (1-2%) Increased LFTs (1-2%) Nasopharyngitis (1-2%) Urinary...
... Show morePregnancy Category Note
Pregnancy
Neonates exposed to antipsychotic drugs during third trimester of pregnancy are at risk for extrapyramidal symptoms or withdrawal symptoms after delivery; these complications vary in severity, with some being self-limited and others requiring ICU support and prolonged hospitalization
Lactation
Unknown if distributed in human breast milk
Present in rat milk
Consider the developmental and health benefits of breastfeeding along with the mother’s clinical need for the drug, and any potential adverse effects on the breastfed infant from the drug or from the underlying maternal condition
Interaction
Coadministration with a strong CYP3A4 inhibitor increases the exposures of cariprazine and its major active metabolite, didesmethylcariprazine (DDCAR), compared to use of cariprazine alone
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