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Uticure 1

tablet-(1gm)
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Incepta Pharmaceuticals Ltd.chevron-right

Generic: Methenamine

Stock AvailableStock: Available
10 Tablets (1 Strip)
৳227.25
৳250
9% OFF

Medicine Overview of Uticure 1 1gm tablet

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Indication

Asymptomatic bacteriuria, Treatment and prophylaxis of chronic, uncomplicated lower urinary-tract infections.

Adult Dose

Oral Asymptomatic bacteriuria, Treatment and prophylaxis of chronic, uncomplicated lower urinary-tract infections. Adult: As methenamine hippurate: 1,000 mg bid. In catheterised patient: 1,000 mg tid. As methenamine mandelate: 1,000 mg 4 times daily.

Child Dose

Oral Asymptomatic bacteriuria, Treatment and prophylaxis of chronic, uncomplicated lower urinary-tract infections. Child: <6 yr As methenamine mandelate: 18 mg/kg 4 times daily; 6-12 yr As methenamine hippurate: 500-1,000 mg bid; As methenamine mandelate: 500 mg 4 times daily; >12 yr: As methenamine hippurate: 1,000 mg bid. In catheterised patient: 1,000 mg tid. As methenamine mandelate: 1,000 mg 4 times daily.

Renal Dose

Renal impairment: Contraindicated.

Contraindication

Hypersensitivity. Gout, metabolic acidosis, severe dehydration. Renal and severe hepatic impairment. Concomitant use w/ sulfonamides or alkalinising agents.

Mode of Action

Methenamine is a urinary antibacterial agent. Its action depends on its conversion in acidic urine into formaldehyde, a nonspecific bactericidal agent, that is active against both gram+ve and gram-ve bacteria.

Precaution

Patient w/ indwelling urinary catheters; conditions wherein urine acidification is contraindicated or unattainable (e.g. presence of urea-splitting bacteria in the urine). Mild to moderate hepatic impairment. Childn. Pregnancy and lactation. Not intended for use in upper UTI. Monitoring Parameters Monitor urinalysis, urine culture, LFT. Maintain an acidic urine, or give supplemental acidification (e.g. ammonium Cl, ascorbic acid, methionine), if necessary.

Side Effect

1-10% Dysuria Gastric upset Nausea Rash

Pregnancy Category Note

Pregnancy Category: C Lactation: excreted in breast milk; no adverse effects documented

Interaction

Acetazolamide may inhibit conversion of methenamine into formaldehyde. Potentially Fatal: Risk of crystalluria when given w/ sulfonamides (e.g. sulfamethizole) or urinary alkalinising agents (e.g. potassium citrate).

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Disclaimer

The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.