12-24 Hours
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Gento HC
Gaco Pharmaceuticals(G.A Company Ltd)
Generic: Gentamicin 0.3% + Hydrocortisone Acetate 1% Eye prep
Medicine Overview of Gento HC 10ml Eye Drop
বাংলা
English
Indication
Susceptible infections, Keratitis, Allergic conjunctivitis, Blepharitis, Allergic and inflammatory conditions of the eye, Chronic conjunctivitis, Spring catarrh,
Adult Dose
Ophthalmic
Superficial ophth infections:
Instill 1-2 drops 4 hrly, up to 2 drops hrly in severe cases.
As eye oint: Apply 1/2 inch into the conjunctival sac 2-3 times daily.
Contraindication
History of hypersensitivity to aminoglycoside; pregnancy; hepatic impairment.
Mode of Action
Gentamicin is an aminoglycoside that binds to 30s and 50s ribosomal subunits of susceptible bacteria disrupting protein synthesis, thus rendering the bacterial cell membrane defective.
Hydrocortisone is a corticosteroid used for its anti-inflammatory and immunosuppressive effects. Its anti-inflammatory action is due to the suppression of migration of polymorphonuclear leukocytes and reversal of increased capillary permeability. It may also be used as replacement therapy in adrenocortical insufficiency.
Precaution
Concurrent use of neuromuscular blocking agents; myasthenia gravis, parkinsonism; conditions predisposing to ototoxicity and nephrotoxicity; lactation. Monitor plasma concentrations of gentamicin in patients receiving high doses or prolonged courses, in infants, elderly, patients with renal impairment, cystic fibrosis or significant obesity. Monitor auditory and renal functions.
Side Effect
Allergic contact dermatitis, Transient irritation, burning, stinging, Increased redness, lacrimation
Interaction
Gentamicin: Additive effect w/ other neurotoxic and/or nephrotoxic drugs including cephalosporins, methicillin, amphotericin B, ciclosporin, cisplatin, potent diuretics (e.g. ethacrynic acid, furosemide) and neuromuscular blocking agents (e.g. succinylcholine, tubocurarine). May potentiate the effect of anticoagulants (e.g. warfarin, phenindione). May antagonise the effect of neostigmine and pyridostigmine. Increased risk of hypocalcaemia w/ bisphosphonates. Increased risk of neuromuscular blockade w/ botulinum toxin. Indometacin may increase the plasma concentration of gentamicin in neonates. Hydrocortisone: Thiazides may enhance hyperglycaemia and hypokalaemia caused by corticosteroids. Increased incidence of peptic ulcer or GI bleeding with concurrent NSAIDs admin. Response to anticoagulants altered. Dose of antidiabetics and...
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