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Safety Advices
বাংলা
English
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Accolate 20. Please consult your doctor.
SAFE IF PRESCRIBED
Accolate 20 is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
CONSULT YOUR DOCTOR
Accolate 20 is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
SAFE
Accolate 20 does not usually affect your ability to drive.
SAFE IF PRESCRIBED
Accolate 20 is safe to use in patients with kidney disease. No dose adjustment of Accolate 20 is recommended.
However, inform your doctor if you have an underlying kidney disease.
UNSAFE
Accolate 20 is probably unsafe to use in patients with liver disease and should be avoided. Please consult your doctor.
Inform your doctor if you develop any signs and symptoms of jaundice while taking this medicine.
Medicine Overview of Accolate 20mg Tablet
Introduction
Accolate 20 is a prescription medicine used for asthma prevention and for the treatment of allergy symptoms such as sneezing and runny nose. It reduces inflammation in the airways and make breathing easier. Accolate 20 should be taken on an empty stomach, but take it at the same time to get the most benefit. It is advised to have it 2 hours before exercise if you have exercise-induced asthma. It should be taken as your doctor's advice. The dose and how often you take it depends on what you are taking it for. Your doctor will decide how much you...
... Show moreUses of Accolate 20
- Asthma prevention
Side effects of Accolate 20
Common
- Headache
- Infection
- Nausea
- Diarrhea
- Pain
- Weakness
How to use Accolate 20
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Accolate 20 is to be taken empty stomach.
How Accolate 20 works
Accolate 20 works by blocking the action of leukotriene. It lowers inflammation in the airways and nose to prevent asthma.
What if you forget to take Accolate 20?
If you miss a dose of Accolate 20, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- You have been prescribed Accolate 20 for asthma prevention and for the treatment of allergy symptoms such as sneezing and runny nose.
- Take it on an empty stomach at least 1 hour before or 2 hours after meals.
- It is a relatively safe medicine with very few side effects.
- Take Accolate 20 2 hours before exercising if you have exercise-induced asthma.
- It does not work right away and should not be used to relieve sudden breathing problems. Use your rescue inhaler to control sudden difficulty in breathing.
- Do not discontinue use without consulting your doctor, even if you feel better.
Brief Description
Indication
Chronic asthma
Administration
Should be taken on an empty stomach. Take at least 1 hr before or 2 hr after meals.
Adult Dose
Oral
Chronic asthma
Adult: 20 mg bid.
Hepatic impairment: Contraindicated.
Child Dose
Oral
Chronic asthma
Child: 5-11 yr: 10 mg bid.
>12 yr: 20 mg bid.
Renal Dose
Renal Impairment
Dose adjustment not necessary
Contraindication
Hypersensitivity, hepatic impairment, cirrhosis, acute asthmatic attacks. Lactation.
Mode of Action
Zafirlukast selectively antagonises the leukotriene D4 receptor. It inhibits bronchoconstriction caused by various inhaled antigens or irritants. It is not used in acute asthma attacks.
Precaution
Not indicated for use in the reversal of bronchospasm in acute asthma attacks. Avoid abrupt substitution to oral or inhaled corticosteroids. Renal impairment. Pregnancy and lactation. Monitoring Parameters Monitor for improvements in air flow; monitor closely for sign/symptoms of hepatic injury; periodic monitoring of LFTs.
Lactation: Excreted in breast milk; not recommended
Side Effect
>10%
headache (12.9% in age >12 yr)
1-10%
Abdominal pain (1.8%),Infection (3.5%),Nausea (3.1%),Diarrhea (2.8%),Generalized pain (1.8%),Vomiting (1.5%),Dyspepsia/gastritits (1.3%),Increased ALT (1.5%),Infection (4%),Back pain (2%),Weakness (2%),Myalgia (2%)
Frequency Not Defined
Eosinophilia
Eosinophilic pneumonia
Vasculitis
Malaise
Bleeding
Bruising
Potentially Fatal: Severe hepatotoxicity.
Interaction
May enhance anticoagulant activity of warfarin resulting to increased prothrombin time. Decreased plasma levels w/ theophylline, terfenadine and erythromycin. Increased plasma levels w/ fluconazole and high dose aspirin.
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