The Anti-double-stranded DNA (Anti-dsDNA) test is a blood test primarily used to help diagnose and monitor systemic lupus erythematosus (SLE), an autoimmune disease. This test detects antibodies against double-stranded DNA, which are often present in individuals with lupus. A positive result can indicate disease activity and severity, as these antibodies are associated with kidney involvement and other serious manifestations of lupus. The Anti-dsDNA test is particularly useful for differentiating lupus from other autoimmune disorders and can aid in assessing the effectiveness of treatment over time.

Systemic Lupus Erythematosus, Lupus Nephritis, Sjogren Syndrome, Mixed Connective Tissue Disease

The normal range of anti-dsDNA is as follows: Values Remarks ≤4 IU/ml Negative 5–9 IU/ml Intermediate ≥10 IU/ml Positive

The immune system has several components. In the case of lupus, these components attack the body's cells for defence. There are two types: complement 3 (C3) and complement 4 (C4). Lupus is suspected if an anti-ds DNA test report shows low C3 levels or low C4 levels. Lupus is regulated in the system if C3 and C4 levels are moderate. The interpretation of anti-dsDNA test reports depends on a person's clinical case and signs and symptoms. The increased anti-dsDNA values in the blood suggest lupus. Elevation in anti-ds DNA values means: The person likely has lupus. It is confirmatory of lupus when anti-dsDNA is positive along with clinical signs and symptoms of lupus. Systemic lupus erythematosus is about to flare up. Systemic lupus erythematosus has flared up already. There could be a continuous inflammatory process due to autoimmune disease. There is kidney damage in the person who has lupus nephritis. Decrease in anti-ds DNA value means The patient is having a disease with a negative status of Anti-dsDNA. Negative anti-dsDNA does not rule out the possibility of lupus. Low values of Anti-ds DNA could be due to Autoimmune illnesses Sjögren syndrome Mixed connective tissue disease (MCTD) Anti-dsDNA chart can be positive due to Chronic hepatitis Primary biliary cirrhosis Infectious mononucleosis Medications like procainamide or hydralazine Lupus symptoms sometimes overlap with those of a variety of different conditions, making diagnosis difficult. Consulting the doctor is essential for these symptoms. The doctor can perform clinical examinations to make an accurate diagnosis.

A simple blood sample is taken for the anti-dsDNA test.