Diagnostic Marker for Goodpasture Syndrome and Autoimmune Kidney Disorders.
The Anti-GBM Antibody (IgG) test detects the presence of autoantibodies against the glomerular basement membrane (GBM) in the kidneys. These antibodies are associated with autoimmune conditions such as Goodpasture’s syndrome, which affects the kidneys and lungs.
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How our test process works!
Overview:
The Anti-GBM antibody test detects IgG autoantibodies targeting the glomerular basement membrane (GBM) in the kidneys and alveolar basement membrane in the lungs. It is primarily used to diagnose Anti-GBM Disease, including Goodpasture’s Syndrome, which can cause rapidly progressive glomerulonephritis and pulmonary hemorrhage.
Risk Assessment:
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Who Should Be Tested?
- Patients with rapidly progressive glomerulonephritis (RPGN)
- Patients with alveolar hemorrhage and hematuria
- Patients suspected of Goodpasture’s Syndrome
- Those with unexplained hemoptysis, anemia, or renal failure
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Risk Factors for Anti-GBM Disease:
- Genetic predisposition (HLA-DR15, HLA-DR4)
- Smoking
- Exposure to hydrocarbons or certain medications
- Infections triggering an immune response.
Normal Range:
- Typically < 20 U/mL or negative (<1:10 titer)
Next Steps if Positive:
- Immediate referral to a nephrologist and/or pulmonologist
- Plasmapheresis (Plasma Exchange Therapy)
- Corticosteroids and Immunosuppressive Therapy (Cyclophosphamide, Rituximab, etc.)
- Dialysis if renal failure is advanced.
Interpretation of Results:
| Result | Interpretation |
|---|---|
| Negative (< 20 U/mL or <1:10 titer) | No significant Anti-GBM antibodies detected. Unlikely to have Anti-GBM disease. |
| Borderline (20–30 U/mL) | Low levels of Anti-GBM antibodies. May indicate early disease or a false-positive; clinical correlation needed. |
| Positive (> 30 U/mL or >1:10 titer) | Suggestive of Anti-GBM disease. Requires further clinical evaluation and possibly a kidney/lung biopsy. |
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Strongly Positive (>100 U/mL): High risk of active Goodpasture’s Syndrome. Immediate intervention needed.
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Additional Testing:
- ANCA (Anti-Neutrophil Cytoplasmic Antibody) testing: Some patients may have both Anti-GBM and ANCA-associated vasculitis.
- Kidney Biopsy: If renal involvement is suspected.
Sample Type:
- Serum (Blood Test)
- Sample is collected via venipuncture and analyzed using ELISA (Enzyme-Linked Immunosorbent Assay) or IFA (Indirect Immunofluorescence Assay).
Frequently Asked Question
Anti Glomerular Basement Membrane Protein IGG / Anti GBM Ab
Diagnostic Marker for Goodpasture Syndrome and Autoimmune Kidney Disorders.
The Anti-GBM Antibody (IgG) test detects the presence of autoantibodies against the glomerular basement membrane (GBM) in the kidneys. These antibodies are associated with autoimmune conditions such as Goodpasture’s syndrome, which affects the kidneys and lungs.
Covid Safety
Assured
Free Report
Counselling