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Sugana 1/4

Tablet-(1mg+4mg)
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Pacific Pharmaceuticals Ltd.

Generic: Glimepiride + Rosiglitazone

1 Tablet
৳ 9.29
৳ 10
7% OFF

Medicine Overview of Sugana 1/4 1mg+4mg Tablet

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Introduction

Sugana 1/4 is a combination medicine that helps control blood sugar levels. This medicine is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus. It helps in proper utilisation of insulin, thereby lowering the blood sugar levels. Sugana 1/4 should be taken in the dose and duration as advised by your doctor. It must be taken with food to avoid stomach upset. If you miss a dose, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose. Overdose may lead to low blood sugar (hypoglycemia). Some people may develop hypoglycemia (low blood sugar level) when this medicine is taken along with other antidiabetic medicines, alcohol or upon skipping a meal. Monitor your blood sugar levels regularly while taking it. Other common side effects of this medicine include nausea, taste changes, diarrhea, stomach pain, headache, edema (swelling), blurred vision, bone fracture, and respiratory tract infection. Before taking this medicine, inform your doctor if you have any kidney, liver or heart problems. Pregnant or breastfeeding women should also consult their doctor before taking it. Your doctor will check your kidney function tests before starting treatment with it. Avoid excessive alcohol intake while taking it as this may increase the risk of developing some side effects.

Uses of Sugana 1/4

  • Type 2 diabetes mellitus

Side effects of Sugana 1/4

Common
  • Hypoglycemia (low blood glucose level)
  • Nausea
  • Taste change
  • Diarrhea
  • Stomach pain
  • Headache
  • Edema (swelling)
  • Weight gain
  • Blurred vision
  • Bone fracture
  • Respiratory tract infection

How to use Sugana 1/4

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Sugana 1/4 is to be taken with food.

How Sugana 1/4 works

Sugana 1/4 is a combination of three antidiabetic medicines: Glimepiride, Metformin and Pioglitazone. They work by different mechanisms to provide better control of blood sugar when single or dual therapy is not effective. Glimepiride is a sulfonylurea which works by increasing the amount of insulin released by the pancreas in order to lower the blood glucose. Metformin is a biguanide. It works by lowering glucose production in the liver, delaying glucose absorption from intestines and increasing the body's sensitivity to insulin. Pioglitazone is a thiazolidinedione which further increases insulin sensitivity.

Quick Tips

  • Take it with food to lower your chance of having an upset stomach.
  • It may cause hypoglycemia (low blood sugar level) when used with other antidiabetic medicines, alcohol or if you delay or miss a meal.
  • Always carry some sugary food or fruit juice with you in case you experience hypoglycemic symptoms such as cold sweats, cool pale skin, tremor, and anxiety.
  • Your doctor may check your liver function regularly. Inform your doctor if you develop symptoms such as abdominal pain, loss of appetite, or yellowing of the eyes or skin (jaundice).

Brief Description

Indication

Type 2 DM

Adult Dose

Type 2 Diabetes Starting Dose: 1 tab (4mg/1mg) qDay with first meal of day Titrate: glimepiride component increased not to exceed 2 mg q1-2 week Not to exceed 8 mg rosiglitazone/4 mg glimepiride Elderly: Starting Dose: 1 tab (4mg/1mg) qDay with first meal of day Titrate dose carefully Hepatic impairment Starting dose: 1 tab (4mg/1mg) qDay with first meal of day; titrate carefully ALT <2.5 xULN: Use caution ALT >2.5 xULN: Do not administer ALT >3 xULN or jaundice after initiating therapy: Discontinue

Child Dose

Safety and efficacy not established

Renal Dose

Renal impairment, starting dose: 1 tab (4mg/1mg) qDay with first meal of day; titrate carefully

Contraindication

Patients with established Class III or IV heart failure is contraindicated.

Mode of Action

Glimepiride: Initial effect to increase insulin secretion from beta cells; may also decrease rate of hepatic glucose production and increase insulin receptor sensitivity. Rosiglitazone: Lowers glucose by improving target cell response to insulin without increasing pancreatic cell secretion; activates nuclear peroxisome proliferator-activated receptor gamma, which influences the production of gene products involved in glucose and lipid metabolism.

Precaution

Hypoglycemia: All sulfonylurea drugs are capable of producing severe hypoglycemia. Proper patient selection, dosage, and instructions are important to avoid hypoglycemic episodes. Debilitated or malnourished patients and those with adrenal, pituitary, renal, or hepatic insufficiency are particularly susceptible to the hypoglycemic action of glucose lowering drugs. Loss of Control of Blood Glucose: When a patient stabilized on any antidiabetic regimen is exposed to stress such as fever, trauma, infection, or surgery, a temporary loss of glycemic control may occur. Edema: Combination of Glimepiride and Rosiglitazone should be used with caution in patients with edema. Since thiazolidinediones, including Rosiglitazone can cause fluid retention, which can exacerbate or lead to congestive heart failure, Combination of Glimepiride and Rosiglitazone should be used with caution in patients at risk for heart failure. Weight Gain: Dose-related weight gain was seen with Rosiglitazone alone and in combination with other hypoglycemic agents. Hepatic Effects: Liver enzymes should be checked prior to the initiation of therapy with combination of Glimepiride and Rosiglitazone in all patients and periodically thereafter per the clinical judgment of the healthcare professional. Lactation: not known if crosses into breast milk, avoid

Side Effect

1-10% Edema (3%),Myocardial infarction (<3%),Cerebrovascular accident (<2%),Cardiac failure (<3%),Headache (3-6%),Hypoglycemia (4-6%),Bone fracture (<8%),Nasopharyngitis (4-5%) <1% Weight gain,Cardiac failure,Increased serum ALT

Interaction

Glimepiride: Salicylates, sulfonamides, chloramphenicol, clarithromycin, coumarin anticoagulants, probenecid, CYP2C9 inhibitors, fibric acid derivatives, disopyramide, fluoxetine, quinolones, ACE inhibitors, MAOIs and ?-blockers may potentiate the hypoglycaemic action of glimepiride. Thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, oestrogens, phenytoin, nicotinic acid, sympathomimetics and CYP2C9 inducers may reduce hypoglycaemic effect of glimepiride. Reduced plasma concentration w/ colesevelam. Rosiglitazone: Increased plasma conc w/ gemfibrozil. Decreased plasma conc w/ rifampicin.

Buy Sugana 1/4 from Arogga

In Bangladesh, you can get the original Sugana 1/4. Select your favorite one from a large collection of medicine products. Order from App to get more offers and better experience.

What is the price of Sugana 1/4 in Bangladesh?

The latest price of Sugana 1/4 in Bangladesh is 9.29৳. You can buy Sugana 1/4 at the best price from Arogga. Order online through our website or mobile app and get fast home delivery anywhere in Bangladesh. Cash on Delivery (COD) is available all over Bangladesh.

Frequently Questions & Answers

Is the product authentic?

Yes. Arogga sources all medicines and health products directly from trusted suppliers, distributors, or manufacturers. Every product is verified before delivery.

Does Arogga deliver all over Bangladesh?

Yes, Arogga delivers nationwide. You can order from anywhere in Bangladesh.

Is Cash on Delivery(COD) available?

Yes, Cash on Delivery is available across Bangladesh for most products.

How long does delivery take?

Delivery usually takes 24–48 hours inside Dhaka and 3–5 days outside Dhaka, depending on location and courier load.

Can I return or replace the product?

If the product is damaged, incorrect, or expired, you can request a replacement or refund according to Arogga’s return policy.

Safety Advices

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UNSAFE
It is unsafe to consume alcohol with Sugana 1/4.
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CONSULT YOUR DOCTOR
Sugana 1/4 may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
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SAFE IF PRESCRIBED
Sugana 1/4 is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby. Monitor the breastfed baby’s blood sugar during treatment with Sugana 1/4
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CAUTION
Your ability to drive may be affected if your blood sugar is too low or too high. Do not drive if these symptoms occur.
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CAUTION
Sugana 1/4 should be used with caution in patients with kidney disease. Dose adjustment of Sugana 1/4 may be needed. Please consult your doctor. Use of Sugana 1/4 is, however, not recommended in patients with severe kidney disease. Regular monitoring of kidney function test is advisable while you are taking this medicine.
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CAUTION
Sugana 1/4 should be used with caution in patients with liver disease. Dose adjustment of Sugana 1/4 may be needed. Please consult your doctor. Use of Sugana 1/4 is not recommended in patients with severe liver disease.

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Disclaimer

The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.